Synthesis, Characterization and Evaluation of New Oxazepine Derivatives for Antibacterial Activity

Abstract

Maleic anhydride was reacted with previously synthesized Schiff bases in the presence of dry benzene, aiming to form a heptad ring derived from oxazepine. This study addresses the need for new bioactive compounds due to increasing bacterial resistance to traditional antibiotics. Physical characteristics such as yield, color, and melting point, along with spectral data (IR and NMR), confirmed the successful synthesis of the compounds. Their antibacterial activity was evaluated against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive), showing comparative results to the antibiotic amoxicillin. The findings suggest potential applications of these oxazepine derivatives as antimicrobial agents.