Effect of CETP Gene Taq1.B Polymorphism on Lipid Profile Abnormalities in Iraqi Type 2 Diabetic Patients

Abstract

Previous "studies have evaluated the associations between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism, the risk of developing diabetes mellitus. The objective of this study was to investigate whether a relationship exists between CETP gene on lipid profile abnormalities in Iraqi diabetic patients. A meta-analysis of  was conducted to clarify the associations of the CETP TaqIB polymorphism with HDL-C concentration and the diabetes mellitus. In this study 160 Iraqi subject were enlist, 90 patients with DM and 70 as a control. Table (1) shows serum lipid results of the population study , (TC , TG, LDL-C, and VLDL-C) were significantly higher (P<0.0001) except HDL-C was lower in the pa¬tient group compared to the control group (P<0.0001). There were more male (75.55%) than female (24.4%) with T2DM in this study. The high proportion of males in this study may be due to the nature of population admitting to this hospital in that more of them seek medical attention than women under favor of having more free time because most of them were retired. included in the association between the CETP TaqIB polymorphism and the concentration of HDL-C. Various single nucleotide polymorphisms have been depicted in the CETP gene. It has been accounted for that the rs708272 Taq1 B (g.5454G>A) polymorphism impacts HDL-C focus. Subsequently, the point of this assessment was to evaluation the polymorphism of CETP gene at Taq1B site and its impact on serum lipid in Iraqi patients with lipid issue. We chose CETP Taq1 B polymorphism since a couple of assessments itemized its relationship to the HDL level and considering the way that we didn't find any Iraqi examination discussing this polymorphism" of the CETP gene.