Prediction of Individual Risk Adverse Cardiovascular Events in for a Year after a Heart Attack Myocardium, Taken into Molecular Genetic Factors

Abstract

Myocardial infarction is one of the clinical forms of coronary heart disease, which occurs with ischemic necrosis of an area of the myocardium as a result of occlusion of the coronary artery [1]. The most common cause is thrombosis, which develops when an unstable atherosclerotic plaque is damaged. Due to prolonged ischemia of the heart area, necrosis of cardiomycytes occurs, followed by the formation of a leukocyte shaft. The patient should be admitted to the cardiac intensive care unit as quickly as possible. In the first hours, it is necessary to perform thrombolysis, as well as angioplasty and stenting of the coronary arteries. [3] Myocardial infarction develops in patients aged 40 to 60 years and most often affects men, and is also the leading cause of disability throughout the world. Risk factors include: modifiable factors and non-modifiable factors. Modifiable factors include: smoking (which accompanies narrowing of the coronary arteries), frequent alcohol consumption, obesity BMI=more than 30, low primary physical activity (LPPA), imbalanced diet (the diet, as a rule, is dominated by fats and foods that contribute to increased in the blood LDL, HDL, cholesterol, triglycerides). Non-modifiable factors include: a family history of cardiovascular disease, gender, age (patients over 40 years old), as well as concomitant diseases: type II diabetes mellitus, arterial hypertension, endocrinological disorders, myocardial infarctions suffered in the past. Myocardial infarction is the most common disease and the most common cause of death worldwide. Today, myocardial infarction occurs at a young age. Between the ages of 35 and 50, men get sick 10 times more than women. In 75% of patients who suffer from myocardial infarction, it does not develop suddenly, but a prodormal syndrome is noted, which occurs in three variants: 1) angina with a rapid course, 2) angina, which proceeds calmly, but can turn into unstable angina, 3) attacks of acute coronary insufficiency (ACS), 4) Prinzmetal's angina.