Synthesis, Characterization, and Study of the Biological Activity of Pt(II) Dithiocarbamate Complexes With Dppe and Dppf

Theophylline-dithiocarbamate, a novel ligand, was synthesized by reacting theophylline with carbon disulfide in the presence of NaOH at low temperatures (7-0 °C). Platinum-based complexes of this ligand with tertiary phosphines (dppf and dppe) were prepared in a 1:1 molar ratio (phosphine). These complexes were characterized using physical methods (melting points, molar conductivity, elemental analysis) and spectroscopic techniques (FT-IR, ¹H-NMR, and ³¹P{¹H}-NMR). The antibacterial activity of the ligands and complexes was tested against Escherichia coli and Enterococcus faecium, revealing varying inhibition rates compared to the standard antibiotic, Ciprofloxacin. This study highlights the potential of these complexes as antibacterial agents, contributing to the ongoing search for new antimicrobial compounds.