Study the Relationship between the Levels of Some Adipokines and Toxoplasmosis in Women

Toxoplasma gondii is the parasite that causes toxoplasmosis, a disease that affects both humans and animals and is common in a variety of demographic groups. There is uncertainty and variance in patients' immunity due to T. gondii's dormant state. Thus, the purpose of this study was to determine the connection between female toxoplasmosis and the levels of specific adipokines. Between May and August of 2024, 140 subjects visited Azadi Teaching Hospital and Kirkuk Teaching Hospital. The experimental study was conducted in Kirkuk, Iraq, in private laboratories. A control group of fifty disease-free, healthy volunteers was also included. The results showed that the total of 140 blood sample collected from obese patient included in the study, 51(36.4%) was IgG positive. While 15(10.7%) was IgM positive, anti-T. gondii IgG and IgM seropositivity was found to be 3(2.1%) in patients. The findings showed that there is a strong association between obesity and infection with T. gondii in women, where it is noted that the group of women who weighed more than 30 kg/m2 had the highest infection, as the percentage of anti-T. gondii IgG reached 36 (70.6%) out of 51 positive results, and anti-T. gondii IgM reached 10 (66.7%) out of 15 positive results. chemerin showed significant (P≤0.05) elevated in Toxoplasma patients (3.84±0.13) compared with control group (1.67±0.19). Serum leptin showed significant (P≤0.05) elevated in Toxoplasma patients (51.04±4.61) compared with control group (8.49±1.43). Based on the results of the current study, a strong association was found between obesity and T. gondii infection in women. In addition, T. gondii infection led to increased levels of both chemerin and leptin.