The Value of Using Operative Release Vs. Local Corticosteroid Injection in The Treatment of Entrapment Syndrome of The Median Nerve at The Wrist

Carpal Tunnel Syndrome Median Nerve Entrapment Corticosteroid Injection Carpal Tunnel Release

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August 27, 2026

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Aim of the study: To assess the value of using operative release of carpal tunnel vs. local corticosteroid injection to treat moderate cases of carpal tunnel syndrome(CTS) .

Patients and method : A  prospective randomized trial of 42 patients  with symptoms of entrapment of the median nerve of a moderate degree  at the wrist during the period between march 2022 and march 2024.Patients were divided into two group , one group treated by local steroid injection(Group 1) and the other group treated by open carpal tunnel release(Group 2). Global Symptoms Score(GSS) was used for evaluation at baseline , one month, three months and six months.

Results:21 patients treated by local steroid injection in group 1(LSI) and 21 patients treated by open carpal tunnel release (OCTR) in group 2.The mean age for patients in group 1 was 40.6 years and mean age for patients in group 2 was 41.1 years with no statistical  significant difference regarding age, sex distribution, side of hand affection, and other clinical symptoms(hand pain and nocturnal paresthesia) and clinical tests ( p value >0.05).Baseline mean GSS was 31.3 for group 1 and 31.16 in group 2 , which was  statically  insignificant(p value >0.05).At one month mean GSS was 10.8 in LSI group and 11.33 in OCTR group ,This was without   significant difference(p value >0.05).Follow -up at 3rd month revealed a mean GSS at 12.3  for group 1 and 10.33 for group 2  with p value >0.05. After 6 months mean GSS in group treated by OCTR was 7.3 and 21.5 for group treated by LSI(Group 1),there was a difference statistically significant  (p value <0.05) and surgical treatment was better option for long term  effect last up to six months.

Conclusion: Local steroid injection provide short-term efficacy extend up to three months  while OCTR is more effective treatment for long-term symptomatic relief of moderate  CTS ,which extend up to six months in this study.