Emerging Biomarkers in Cancer Diagnosis and Prognosis
Keywords:
Cancer biomarkers, early diagnosis, early diagnosisprognosis, precision medicineAbstract
Biomarkers play a crucial role in cancer diagnosis and prognosis, enabling early detection, personalized treatment, and therapeutic monitoring. Despite significant advancements, challenges remain in identifying reliable, specific, and clinically applicable biomarkers. This study reviews recent developments in biomarker discovery, focusing on genomic, proteomic, and metabolomic markers, as well as the emerging role of liquid biopsies. Using a multidisciplinary approach, we analyze advancements in biomarker research, the integration of artificial intelligence for biomarker identification, and the implications for precision medicine. Findings suggest that novel biomarkers enhance diagnostic accuracy, improve treatment outcomes, and offer new opportunities for targeted therapies. The results highlight the need for further validation and standardization to ensure clinical reliability. This study underscores the potential of biomarkers to revolutionize cancer management and contribute to the future of precision oncology.
References
E. G. Ramirez-Valles, A. Rodríguez-Pulido, M. Barraza-Salas, I. Martínez-Velis et al., "A Quest for New Cancer Diagnosis, Prognosis and Prediction Biomarkers and Their Use in Biosensors Development," 2020. ncbi.nlm.nih.gov
L. Neves Rebello Alves, D. Dummer Meira, L. Poppe Merigueti, M. Correia Casotti et al., "Biomarkers in Breast Cancer: An Old Story with a New End," 2023. ncbi.nlm.nih.gov
S. Das, M. K. Dey, R. Devireddy, and M. R. Gartia, "Biomarkers in cancer detection, diagnosis, and prognosis," Sensors, 2023. mdpi.com
A. Bodaghi, N. Fattahi, and A. Ramazani, "Biomarkers: Promising and valuable tools towards diagnosis, prognosis and treatment of Covid-19 and other diseases," Heliyon, 2023. cell.com
A. Passaro, M. Al Bakir, E. G. Hamilton, M. Diehn, and F. André, "Cancer biomarkers: emerging trends and clinical implications for personalized treatment," Cell, 2024. cell.com
B. Krishna Prasanth, S. Alkhowaiter, G. Sawarkar, B. Divya Dharshini et al., "Unlocking Early Cancer Detection: Exploring Biomarkers, Circulating DNA, and Innovative Technological Approaches," 2023. ncbi.nlm.nih.gov
B. N. Chorley, E. Atabakhsh, and G. Doran, "Methodological considerations for measuring biofluid-based microRNA biomarkers," Critical Reviews in ..., 2021. tandfonline.com
V. Garzarelli, F. Ferrara, E. Primiceri, and M. S. Chiriacò, "Biofluids manipulation methods for liquid biopsy in minimally-invasive assays," MethodsX, 2022. sciencedirect.com
L. Dayon, O. Cominetti, and M. Affolter, "Proteomics of human biological fluids for biomarker discoveries: technical advances and recent applications," Expert review of proteomics, 2022. [HTML]
M. W. Farha and S. S. Salami, "Biomarkers for prostate cancer detection and risk stratification," 2022. ncbi.nlm.nih.gov
M. Pourmadadi, A. Moammeri, and A. Shamsabadipour, "Application of various optical and electrochemical nanobiosensors for detecting cancer antigen 125 (CA-125): a review," Biosensors, 2023. mdpi.com
S. Rao, D. A. Smith, E. Guler, E. G. Kikano, M. A. Rajdev, "Past, present, and future of serum tumor markers in management of ovarian cancer: a guide for the radiologist," Radiographics, 2021. rsna.org
A. Margoni, A. N. Gargalionis, "CA-125: CA72-4 ratio− towards a promising cost-effective tool in ovarian cancer diagnosis and monitoring of post-menopausal women under hormone treatment," *Journal of Ovarian*, 2024. springer.com
P. Ahluwalia, K. Ballur, T. Leeman, A. Vashisht et al., "Incorporating Novel Technologies in Precision Oncology for Colorectal Cancer: Advancing Personalized Medicine," 2024. ncbi.nlm.nih.gov
A. I. Robles, K. Standahl Olsen, D. W.T. Tsui, V. Georgoulias et al., "Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway," 2016. ncbi.nlm.nih.gov
S. J Mandrekar and D. J Sargent, "Genomic advances and their impact on clinical trial design," 2009. ncbi.nlm.nih.gov
H. D. Shukla, "Comprehensive Analysis of Cancer-Proteogenome to Identify Biomarkers for the Early Diagnosis and Prognosis of Cancer," 2017. ncbi.nlm.nih.gov
G. Singh Suri, G. Kaur, G. M. Carbone, and D. Shinde, "Metabolomics in oncology," 2023. ncbi.nlm.nih.gov
K. A. Vermeersch and M. P. Styczynski, "Applications of metabolomics in cancer research," 2013. ncbi.nlm.nih.gov
A. Armakolas, M. Kotsari, and J. Koskinas, "Liquid Biopsies, Novel Approaches and Future Directions," 2023. ncbi.nlm.nih.gov
I. Martins, I. Patrícia Ribeiro, J. Jorge, A. Cristina Gonçalves et al., "Liquid Biopsies: Applications for Cancer Diagnosis and Monitoring," 2021. ncbi.nlm.nih.gov
Z. Habli, W. AlChamaa, R. Saab, H. Kadara et al., "Circulating Tumor Cell Detection Technologies and Clinical Utility: Challenges and Opportunities," 2020. ncbi.nlm.nih.gov
H. J Janse van Rensburg, P. Spiliopoulou, and L. L Siu, "Circulating Biomarkers for Therapeutic Monitoring of Anti-cancer Agents," 2022. ncbi.nlm.nih.gov
L. Ning and H. Huixin, "Topic Evolution Analysis for Omics Data Integration in Cancers," 2021. ncbi.nlm.nih.gov