Synthesis and Characterization of New Imidazole Derivatives and Evaluation of Biological Efficacy

Abstract

The present research involves the synthesis of new imidazole derivatives, known for their good biological activity, prepared by the reaction of Schiff bases with the amino acid glycine in the presence of absolute ethanol in a conventional manner. Physical and spectroscopic techniques, including FT-IR spectroscopy, proton and carbon nuclear magnetic resonance spectroscopy (NMR)-[1H NMR]-[13C], and the determination of the produced compounds' melting point, were used to confirm the structures. The effect of some of the prepared compounds on the growth of two types of bacterial isolates, one of which is Gram-negative (G-), i.e., E. coli, and the other Gram-positive (G+) Staphylococcus aureus, was studied using the antibiotic amoxicillin as a control sample. Some prepared compounds showed good inhibitory activity against the bacterial species used.