Synthesis, Characterization, and Evaluation of the Biological Activity of Novel Oxazepine Compounds Derived From Indole-5-Carboxylic Acid

Abstract

This study focuses on the synthesis and characterization of novel oxazepine compounds derived from indole-5-carboxylic acid. Indole-5-carboxylic acid, a compound known for its diverse biological activities, was used as a starting material to address the need for new antimicrobial agents. The research involved a multi-step process, beginning with the esterification of indole-5-carboxylic acid, followed by the preparation of hydrazide derivatives using benzaldehyde derivatives. These were then subjected to a cyclization reaction with maleic anhydride to produce oxazepine derivatives. The structures of the synthesized compounds were confirmed by Fourier Transform Infrared Spectroscopy (FTIR), and Nuclear Magnetic Resonance (H1-NMR, C13-NMR), ensuring their structural integrity. The biological activity of these oxazepine derivatives was evaluated using the diffusion plate method, revealing significant antibacterial activity. These findings suggest that the synthesized compounds have potential as new antimicrobial agents, contributing to the ongoing search for effective treatments against resistant bacterial strains.